Our paper titled "NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson’s disease" was featured on the cover of Cell Genomics journal's volume 6, issue 7. Link
Harvard Medical School and Mass General Brigham did a joint press release on our paper titled "NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson’s disease." The paper has also been featured in Harvard Gazette, Harvard Brain Science Initiative News, BroadCast (Broad Institute), and MedicalXpress news. Link
Our paper titled "NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson’s disease" is online! Link
I gave an invited talk titled "Network-based rare variant association for complex diseases" at the Primer on Medical and Population Genetics (MPG) series at the Broad Institute. MPG primer is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tools for biostatistics, computational genomics, and variant annotation. Link
I was invited as an expert panelist to participate in the working session on "Emerging issues in higher education: AI integration, digital transformation, and smart learning ecosystem" at the South Asian Regional Conference on Higher Education (SARCHE) 2026. Link
I gave an invited talk titled "From Networks to Subtypes: Statistical Frameworks for Mechanistic Insights into Complex Disease Genetics" in the ACM Seminar Series at BUET, Dhaka, Bangladesh
At the 75 Years Jubilee celebrations of Holy Cross College, I was awarded the Alumni Excellence Award in Research and Academia, along with 24 other distinguished alumni in multiple different fields. Link
I gave an invited talk titled "From Networks to Subtypes: Statistical Frameworks for Mechanistic Insights into Complex Disease Genetics" in the Bioinformatics Seminar Series at MIT. Link
Check out my poster titled "Uncovering novel disease mechanisms through network-aware rare variant testing with NERINE" in the Statistical Genetics and Genetic Epidemiology track at ASHG on Friday, Oct 17 in the afternoon poster session. Link
Check out our new preprint on bioRxiv titled "A single-cell genetic colocalization test improves power and resolves disease-mediating cell types." Link
Check out my poster titled "Latent structure modeling of genetic heterogeneity in complex diseases" at GRC and GRS human genetics and genomics meetings. Link
I gave a talk titled "Network-based association of rare variants in complex traits and diseases" at the IGVF consrtium's coding variant focus group meeting.
Check out my talk titled "NERINE: Network-based association test for rare variants in complex traits and diseases" during the C28 Machine Learning and Statistics session on Tuesday, June 4, 2024 at 11 am. Link
I gave an invited talk titled "Network-based genomics approaches for rare variants in alpha-synucleinopathies" in the AD/PD Seminar Series at Ann Romney Center for Neurologic Diseases, Mass General Brigham.
Our abstract titled "NERINE: Network-based association test for rare variants in complex traits and diseases" has been accepted for oral presentation at the "Machine Learning and Statistics" session of the ESHG 2024, Berlin, Germany. The talk is scheduled to happen on June 4 at 11 am.
Check out our latest preprint titled "Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies." Link
In a commentary about our paper titled "Low-frequency inherited complement receptor variants are associated with purpura fulminans," Dr. Christoph Q. Schmidt describes "The authors use whole-exome germ line sequencing to analyze whether a set of 27 complement genes is associated with PF. Uncovering much-needed new pathophysiological clues could enable better therapy for patients with PF in the future, but finding new and meaningful connections from a haystack full of molecular possibilities is not trivial. Using a recently described rarity variant trend test (RVTT) method the authors assess the combined effect of multiple complement gene variants predicted to result in an altered phenotype. Teasing out the aggregate effect is of importance because the rare variants in question do not have sufficient statistical power to be individually associated with purpurea fulminans." Link
Talk Title: "Network-based approaches for rare variant association in complex diseases." on Wed, 02/14/2024
Talk title: Network-based approaches for rare variant association in complex diseases, Lab: Sunyaev, Date: 2/8/24
Our paper titled "Low-frequency inherited complement receptor variants are associated with purpura fulminans" has been accepted for publication in Blood. Link
Talk Title: Network-based rare variant association testing in dichotomous traits, Date: 5/16/2023
Talk title: Computational Biology in the 21st Century: Untangling Health and Disease, Date: 2/18/2023
Our manuscript titled "The missing link between genetic association and regulatory function" has been accepted for publication in eLife. Link
I was featured on the "Faces of Cell" series for being an author on the seminal Cell paper "The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability." Link
Our study titled "The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability" led by Dr. Erinc Hallacli is out on Cell! Glad to be a part of it. Link